Pregnancy fatigue in the first trimester is often described as an overwhelming, bone-deep exhaustion that no amount of coffee could fix — not that you want coffee, because morning sickness may have ruined that for you too. It is fundamentally different from being tired after a long day. Many people say it feels like they have been sedated, with heavy limbs and an irresistible pull toward sleep.
The primary driver is progesterone, which rises rapidly in early pregnancy and has a powerful sedating effect. At the same time, your body is working overtime: blood volume begins increasing toward an eventual 50 percent gain, your heart rate rises, your metabolism ramps up, and you are building the placenta — a brand new organ. All of this happens in the first trimester, often before you even look pregnant.
Third-trimester fatigue has a different flavor. By then, the exhaustion comes from carrying 25 to 35 extra pounds, dealing with disrupted sleep, frequent urination, and the sheer physical effort of moving through the day with a full-term baby on board.