Your baby's age is the single most important factor in deciding how urgently a fever needs to be evaluated. This is because a baby's immune system matures dramatically over the first year of life, and the younger the baby, the higher the risk that a fever signals something serious.
Under 1 month (neonate): Any rectal temperature of 100.4F or higher is an emergency. Go to the ER. Do not wait for a callback. Do not pass Go. Neonates are uniquely vulnerable to bacterial infections — their immune systems have almost no track record of fighting pathogens, and infections like sepsis, meningitis, and urinary tract infections can escalate alarmingly fast. The ER will run blood tests, collect urine, and may perform a lumbar puncture. This sounds frightening, but it is the standard of care, and it saves lives.
1 to 3 months: A fever of 100.4F or higher still requires immediate medical attention. Call your pediatrician. If you reach them, they will likely want to see the baby the same day or direct you to the ER. If you cannot reach your pediatrician within 15 to 30 minutes, go to the ER. The risk of serious bacterial infection has decreased compared to the first month but remains meaningfully elevated.
3 to 6 months: The calculus starts to shift. A fever of 101F to 102F in an otherwise well-appearing baby — eating reasonably well, making eye contact, not lethargic — can often be managed with a call to your pediatrician during office hours. A fever of 102F or higher, especially with decreased feeding or unusual behavior, warrants a prompt call and likely same-day evaluation. Your pediatrician may ask you to come in or may recommend the ER depending on the situation.
6 to 24 months: This is where behavior becomes more important than the thermometer reading. Fevers are incredibly common in this age group — most babies get 8 to 10 viral infections in their first two years, and most of those come with a fever. A baby with 102F who is drinking, playing between fussy periods, and making wet diapers is generally safe for home management with a pediatrician call if it persists beyond 24 to 48 hours. Focus on how your baby is acting, not the number.