Saliva is not just water — it contains digestive enzymes (like amylase and lipase) designed to start breaking down food. When saliva sits on skin constantly, those enzymes start breaking down the skin barrier too. Add friction from constant wiping, moisture from the never-ending drool stream, and the thin, sensitive skin of a baby's face, and you get irritation.
Drool rash typically shows up between 3 and 6 months — right when developmental drooling kicks in — and often gets worse during active teething periods. Teething does not cause more saliva production (despite what everyone says), but the discomfort of emerging teeth does make babies put more things in their mouths and keep their mouths open more, allowing more drool to escape.
The rash is most common on the chin, around the mouth, and in the neck folds — anywhere drool pools and sits. In heavy droolers, it can extend down the chest if drool soaks through clothing.