The evidence-based approach to teething relief is almost disappointingly simple. Cold, pressure, and appropriate pain relief. That is the entire list of what has been shown to help.
Cold reduces inflammation and provides mild local numbing. This is why chilled teething rings, cold washcloths, and refrigerated spoons provide relief — they bring down the inflammation that makes gums sore.
Pressure activates mechanoreceptors in the gum tissue that can modulate pain signals. This is why babies instinctively want to bite and chew during teething — counter-pressure on the eruption site literally helps with the pain. Teething toys, your clean finger, and firm foods all leverage this mechanism.
Systemic pain relief (acetaminophen and ibuprofen) addresses pain through the same pathways that manage any other pain. They are safe, effective, well-studied in infants, and endorsed by the AAP for teething pain. Ibuprofen has the added benefit of anti-inflammatory action, which may be particularly helpful for the swelling component.
These recommendations are unsexy. You will not find them promoted by influencers or featured in teething product ads. But they are what works, and they are what is safe. The flashier alternatives — gels, tablets, necklaces, essential oils — range from ineffective to genuinely dangerous.