Here is a simplified framework:
Choose Bobbie if: organic ingredients, lactose-only carbohydrate, and a shorter ingredient list are priorities for you. You are comfortable with the subscription model (or can access it at a nearby retailer). Your budget can absorb the slightly higher cost. You were considering importing European formula and want a domestic, FDA-registered alternative.
Choose Enfamil if: you value the MFGM bioactive addition, want the widest possible retail availability, or your baby is already doing well on it. Enfamil also has the broadest range of specialty formulas (Gentlease, Nutramigen, AR) if your baby needs something beyond standard formula.
Choose Similac if: you value the HMO additions, prefer the no-palm-olein fat profile, or your baby is already thriving on it. Like Enfamil, Similac offers a comprehensive range of specialty options.
Choose a store brand if: budget is a priority and you want the same FDA-regulated nutrition at 30-50% lower cost. Store brands do not offer MFGM, multiple HMOs, or organic certification, but they meet all FDA nutritional requirements.
The honest truth: for a healthy, full-term baby, all of these options will support normal growth and development. The "best" formula is the one your baby tolerates well, that you can access reliably, and that does not cause financial stress. Everything else is optimization at the margins.
For a comparison of European imports, see our HiPP vs. Holle guide. For the gentle and sensitive lines, see our Enfamil Gentlease vs. Similac Sensitive guide.